British scientists have discovered a key molecule linked to birth defects and miscarriage.
Researchers at the University of Edinburgh carried out tests on infected human cytomegalovirus (HCMV) cells and found that blocking a molecule called VCP with a chemical inhibitor stops the virus from multiplying.
The research team says VCP is a component of the infected cell rather than a substance produced by the virus itself and they found chemicals that block VCP activity of VCP are 10 times more powerful at stopping the virus than existing medications that target HCMV directly.
Writing in PLOS Pathogens, they say that targeting the affected cells instead of the virus could also cut the chances of the virus becoming resistant to the therapy.
HCMV is a common infection, affecting at least 30% of the population in the developed world and up to 100% of people in developing countries.
Although it is harmless in healthy individuals, it can be life-threatening for people with a weakened immune system. Infection during pregnancy can lead to hearing loss and intellectual disabilities in unborn babies, the researchers say.
Dr Finn Grey, a senior research fellow at the University of Edinburgh’s Roslin Institute, said: “Human cytomegalovirus infection is an important human disease. By gaining a better understanding of how the virus works, we can develop improved antiviral drugs.
"While more work is required, this study shows the potential of such approaches.”
PLOS Pathogens 12 May 2017
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