Child epilepsy gene found

Researchers have reported the first gene linked to common forms of epilepsy in children.

European researchers say mutations in the GRIN2A gene causes an increase in electrical discharges in the brain.

The findings come from a study of some 400 children with idiopathic focal epilepsy. Gene mutations were found in 7.5% of the children.

The researchers say the finding, reported in Nature Genetics, is the first step in understanding how the gene mutation causes epilepsy.

Researcher Fritz Zimprich, of MedUni Vienna, Austria, said: “We only see the condition as a result of the mutations; we haven’t yet fully discovered the mechanisms behind it.

“What was crucial for our breakthrough was the close cooperation of doctors carrying out clinical research with theoretical researchers."

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nature Genetics 18 July 2013; doi: 10.1038/ng.2728