Three countries have now reported the emergence of drug-resistant strains of swine flu, the World Health Organisation has announced.
So far only three patients have been infected with drug-resistant strains – one in Denmark, one in Japan and one in Hong Kong, the WHO reported.
So far viruses have only proved resistant to Tamiflu, but not to another anti-flu medicine, zanamivir.
WHO said that some 1,000 strains of the H1N1 flu have been tested for drug resistance world-wide and just three found to pose a problem.
A spokesman said: "Based on current information, these instances of drug resistance appear to represent sporadic cases of resistance.
"At this time, there is no evidence to indicate the development of widespread antiviral resistance among pandemic H1N1 viruses."
Globally some 94,500 cases of swine flu have been diagnosed, including some 429 deaths.
Australia has reported ten deaths, Argentina 60 deaths and New Zealand three deaths.
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