SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Google

WWW Englemed
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Heart failure ranked 'less important than potholes'
Tues June 28th - Heart failure is deemed less important than potholes in roads and pavements in the UK, according to an analysis published today. More
Cannabis users' increased risk of hospital admission
Tues June 28th - Canadian researchers have called for curbs on the globally rising levels of recreational cannabis because users have an increased risk of needing emergency care and hospital admission for any cause. More
RECENT COMMENTS
On 09/10/2020 William Haworth wrote:
How long is recovery time after proceedure... on Ablation cuts atrial fibrillat...
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
OUR CLIENTS
THIS WEEK'S STORIES
ENGLEMED HEALTH NEWS

Treatment hope for cognitive symptoms in Parkinson's disease

Tuesday May 17th 2022

Ultra-powerful 7T MRI scanners could help to identify those patients with conditions such as Parkinson's disease who would benefit from new treatments for cognitive symptoms that were previously untreatable, British researchers report today.

Although individuals with Parkinson's disease and progressive supranuclear palsy (PSP), a related disorder, are often treated with drugs such as L-DOPA, which compensate for the severe loss of dopamine, they have little effect on non-motor symptoms.

Now, focus is shifting to noradrenaline, a chemical that plays a critical role in brain functions including attention and arousal, thinking and motivation.

A study last year by Professor James Rowe from the Department of Clinical Neurosciences at the University of Cambridge, and his team found that some people with PSP had lost as much as 90% of the noradrenaline-producing locus coeruleus.

For this study, they wanted to establish if they could study this tiny region of the brain could be studied in patients who are still alive.

They measured changes in the brains of people with Parkinson's disease, PSP, and individuals in good health, with a new ultra-high strength 7T MRI scanner at the Wolfson Brain Imaging Centre.

Normal MRI scanners do not have the resolution to measure the region in living patients, but the new 7T scanners have ultra-strong magnetic fields and can provide resolution at the size of a grain of sand.

The scanners enabled the team to examine the locus coeruleus of the study participants and confirm that the greater the level of damage found in this region resulted in more severe symptoms of apathy, which also led to poorer performance in cognitive tests.

Writing in *Movement Disorders*, they say their findings could offer renewed hope for treatments for these symptoms because some drugs that boost noradrenaline have already been through clinical trials for other conditions and are safe and well tolerated.

In PSP, it is believed damage to the locus coeruleus is caused by a build-up of the junk protein tau. When noradrenaline breaks down, changes are triggered in the tau protein, leading to its accumulation. This then damages the same cells that produce noradrenaline. A similar situation may occur in Parkinson's disease.

Professor Rowe and colleagues are now leading a clinical trial at Cambridge University Hospitals NHS Foundation Trust to see if these drugs alleviate symptoms in PSP.

Joint first author of the study Dr Rong Ye from the Department of Clinical Neurosciences at the University of Cambridge said: "Not every PSP or Parkinson's patient is going to benefit from noradrenaline-boosting drugs. They're more likely to benefit those people with damage to their locus coeruleus - and the greater the damage, the more benefit they're likely to see.

"The ultra-powerful 7T scanner may help us identify those patients who we think will benefit the most. This will be important for the success of the clinical trial, and, if the drugs are effective, will mean we know which patients to give the treatment to. In the long term, this will prove more cost-effective than giving noradrenaline boosters to patients who ultimately would see no benefit."

Ye R, O'Callaghan, C Rua C et al. Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinsonian Disorders. *Movement Disorders* 17 May 2022; DOI: 10.1002/MDS.29072

Tags: Brain & Neurology | UK News

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES