SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Google

WWW Englemed
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
How heart failure risk rises after surgery
Wed June 29th - The development of atrial fibrillation following surgery is an important risk factor for heart failure, researchers report today. More
Brain surgery benefits intracranial pressure
Wed June 29th - Craniectomy for intracranial hypertension offers significant benefit, according to new guidance, triggered by British research. More
RECENT COMMENTS
On 09/10/2020 William Haworth wrote:
How long is recovery time after proceedure... on Ablation cuts atrial fibrillat...
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
OUR CLIENTS
THIS WEEK'S STORIES
ENGLEMED HEALTH NEWS

Nausea drugs linked to increased stroke risk

Thursday March 24th 2022

Drugs commonly used to treat nausea and vomiting after surgery or those caused by migraine or cancer treatment could increase the risk of ischaemic stroke, researchers warn today.

A French study in the latest edition of *The BMJ* say the three antidopaminergic antiemetics (ADAs) it studied - domperidone, metopimazine and metoclopramide - are all associated with an increased risk, especially in the first days of use.

However, the researchers from Inserm and Bordeaux University (Bordeaux Population Health Centre) and Bordeaux CHU found the highest increase was found for metopimazine and metoclopramide.

They believe the potential action of ADAs on blood flow to the brain could explain this higher risk.

For this study, the team identified 2,612 patients - average age 72 and 34% of whom were men - from the nationwide French reimbursement healthcare system database (SNDS).

All had had a first ischaemic stroke between 2012 and 2016 and at least one reimbursement for domperidone, metopimazine or metoclopramide in the 70 days before their stroke.

The research team compared frequencies of the ADA reimbursements between a risk period of 14 days to one day before stroke and three matched reference periods: days -70 to -57, -56 to -43, and -42 to -29 before stroke.

Patients who had had a stroke were then matched by age, sex, and stroke risk factors to a healthy control group of 21,859 randomly selected people who also received an ADA in the same time period.

It was found that among patients with stroke, 1,250 received an ADA at least once in the risk period and 1,060 in the reference periods. This compared to the control group in which 5,128 and 13,165 received an ADA at least once in the risk and reference periods, respectively.

After taking account of potentially influential factors,new users of ADA were found to be at a three-fold increased risk of stroke shortly after treatment started.

Further analysis showed men had a 3.59-fold increased risk.

The risk appeared to increase for all ADAs, the highest increase being found for metopimazine (a 3.62-fold increase) and metoclopramide (a 3.53-fold increase), both of which are drugs that cross the blood-brain barrier.

While this is an observational study, the team says its results show the risk of ischaemic stroke appears to be associated with ADA use.

Bénard-Laribière A, Hucteau E, Debette S et al. Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study. *BMJ* 24 March 2022

[abstract]

Tags: Europe | Gastroenterology | Heart Health | Pharmaceuticals

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES