Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here

WWW Englemed
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
How heart failure risk rises after surgery
Wed June 29th - The development of atrial fibrillation following surgery is an important risk factor for heart failure, researchers report today. More
Brain surgery benefits intracranial pressure
Wed June 29th - Craniectomy for intracranial hypertension offers significant benefit, according to new guidance, triggered by British research. More
On 09/10/2020 William Haworth wrote:
How long is recovery time after proceedure... on Ablation cuts atrial fibrillat...
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote: on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...

Salt in soluble paracetamol linked to cardiovascular disease risk

Thursday February 24th 2022

Soluble paracetamol that contains salt is linked with a significantly increased risk of heart attacks, stroke, heart failure and death, according to a new Chinese study.

The study of nearly 300,000 patients registered with UK GPs found the risk of heart attack, stroke or heart failure after one year for patients with high blood pressure taking sodium-containing paracetamol was 5.6% (122 cases of cardiovascular disease), while it was 4.6% (3051 of cardiovascular disease cases) among those taking non-sodium-containing paracetamol.

The risk of death was also higher: the one-year risk was 7.6% (404 deaths) and 6.1% (5,510 deaths), respectively.

There was a similar increased risk among patients without high blood pressure.

The study, published today in the *European Heart Journal*, was led by Professor Chao Zeng from Xiangya Hospital, Central South University, Changsha.

He and his team analysed data from the UK’s Health Improvement Network and looked at 4,532 patients, all aged 60-90, with high blood pressure who had been prescribed sodium-containing paracetamol.

These were compared with 146,866 patients with high blood pressure who had been prescribed paracetamol without sodium.

They also compared 5,351 patients without high blood pressure who were prescribed sodium-containing paracetamol with 141,948 patients without high blood pressure prescribed non-sodium-containing paracetamol.

Prof Zeng said the team also found the risk of cardiovascular disease and death increased the longer an individual took sodium-containing paracetamol.

“The risk of cardiovascular disease increased by a quarter for patients with high blood pressure who had one prescription of sodium-containing paracetamol, and it increased by nearly a half for patients who had five or more prescriptions of sodium-containing paracetamol,” he said.

“We saw similar increases in people without high blood pressure. The risk of death also increased with increasing doses of sodium-containing paracetamol in both patients with and without high blood pressure.”

Prof Zeng said that clinicians and patients should be aware of the risks associated with paracetamol that contains sodium and avoid unnecessary consumption, especially when the medication is taken for a long period of time.

“Given that the pain relief effect of non-sodium-containing paracetamol is similar to that of sodium-containing paracetamol, clinicians may prescribe non-sodium-containing paracetamol to their patients to minimise the risk of cardiovascular disease and death,” he said.

“People should pay attention not only to salt intake in their food but also not overlook hidden salt intake from the medication in their cabinet.”

Zeng C, Rosenberg L, Li X et al. Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. *European Heart Journal* 24 February 2022; doi:10.1093/eurheartj/ehac059


Tags: Asia | Heart Health | Pain Relief | Pharmaceuticals | UK News

Printer friendly page Printer friendly page

Comment on this article:

<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)