SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Many health workers may already have had COVID-19
Fri August 7th - The majority UK healthcare workers may already have been infected with COVID-19, according to new research out today. More
Common wrist fracture heals well with plaster cast
Fri August 7th - A common wrist fracture in young people can heal as effectively with a plaster cast as surgery, according to a UK trial reported today. More
RECENT COMMENTS
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...
BOOKS ON WOMEN'S HEALTH
guide to breast disorders guide to womb disorders guide to menopause Complete Women's Health: from The Royal College of Obstetricians and Gynaecologists For books and family gift ideas click here
OTHER NEWS OF INTEREST
WOMEN'S HEALTH NEWS FEED
RSS graphic XML Graphic
ENGLEMED HEALTH NEWS

Strong growth factor link to breast cancer

Wednesday March 11th, 2020

Two new studies, reported today, show how the development of breast cancer is linked to the growth hormone called insulin-like growth factor-1.

Both studies used information from the UK Biobank study. The first, based at the International Agency for Research on Cancer (IARC), Lyon, France, looked at links between levels of insulin-like growth factor-1 in the blood and disease risk in 206,263 women.

The second, based at the University of Oxford, UK, used Mendelian randomisation analysis to examine 265 gene variants (single nucleotide polymorphisms) and showed that this link with insulin-like growth factor-1 is likely to be causal.

This study also suggested that four single nucleotide polymorphisms for insulin-like growth factor-binding protein-3 may control the availability of insulin-like growth factor-1.

Both appear today (11 March) in Annals of Oncology.

Dr Neil Murphy of the International Agency for Research on Cancer said: “We found that higher levels of insulin-like growth factor-1 circulating in the blood, as determined by blood measurements and genetic markers, were related to higher breast cancer risk.

“These results support a probable causal role of the insulin-like growth factor pathway in breast cancer development.”

Dr Marc Gunter, also at the International Agency for Research on Cancer, added: “To our knowledge, this is largest single study and the first Mendelian randomisation study to examine the relationship between insulin-like growth factor-1 and breast cancer.

“Importantly, our Mendelian randomisation analyses yielded strikingly similar positive associations between insulin-like growth factor-1 and breast cancer as those found in our observational analyses.

“Taken together, these results provide the strongest evidence to date for a causal role of the insulin-like growth factor pathway in breast cancer development and suggest that altering levels through diet and lifestyle or pharmacological means may be an effective strategy in the primary prevention of breast cancer.”

Murphy, N. et al. Insulin-like growth factor-1 (IGF-1), insulin growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: observational and Mendelian randomization analyses with 430,000 women. Annals of Oncology 11 March 2020; doi: 10.1016/j.annonc.2020.01.066

https://www.annalsofoncology.org/article/S0923-7534(20)36019-1/fulltext

Tags: Cancer | Europe | Genetics | Women's Health & Gynaecology

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES