Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here

WWW Englemed
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
Lockdown leads to double unplanned pregnancies
Fri October 22nd - Unplanned pregnancies almost doubled during the first lockdown in the UK, a major study reports today. More
Promising development in treatment for glioblastoma multiforme
Fri October 22nd - A major advance in brain tumour research could pave the way for personalised treatment for the most deadly form of the disease, British scientists say. More
On 09/10/2020 William Haworth wrote:
How long is recovery time after proceedure... on Ablation cuts atrial fibrillat...
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote: on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...

Antibiotic risk of inflammatory bowel disease

Tuesday August 18th 2020

Taking antibiotics, especially those with greater spectrum of microbial coverage, could increase the risk of new-onset inflammatory bowel disease (IBD), ulcerative colitis and Crohn’s disease, a new study claims today (18 August 2020).

In the largest study so far to link antibiotic therapy and risk of IBD and the research teams from the Karolinska Institutet in Sweden and Harvard Medical School, USA demonstrated that more frequent use of antibiotics was associated with the development of IBD and its subtypes.

Writing in The Lancet Gastroenterology & Hepatology, they say the association between antimicrobial treatment and IBD remained when patients were compared with their siblings.

Lead author Dr Long Nguyen at Massachusetts General Hospital and Harvard Medical School said: “I think this affirms what many of us have suspected—that antibiotics, which adversely affect gut microbial communities, are a risk factor for IBD.

“However, despite this compelling rationale and seemingly intuitive presumption, there have been no population-scale investigations to support this hypothesis until now.”

The researchers used the Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) study to identify almost 24,000 new IBD cases - of whom 16,000 had ulcerative colitis and 8,000 Crohn’s disease – and compared them with 28,000 siblings and 117,000 controls from the general population.

Prior use of antibiotics was associated with a nearly two times increased risk of IBD after adjusting for several risk factors, while increased risk was noted for both ulcerative colitis and Crohn’s disease, with the highest estimates corresponding to broad-spectrum antibiotics.

This new study differs from previous studies because it was larger and all eligible patients with new-onset IBD from a population-based register were followed over a ten-year period, limiting selection bias.

Senior author Professor Jonas F Ludvigsson, paediatrician at Örebro University Hospital, and professor at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, said: “To identify risk factors for IBD is important, and ultimately our aim is to prevent the disease. Our study provides another piece of the puzzle and even more reason to avoid using antibiotics needlessly.”

Nguyen LH, Örtqvist AK, Cao Y et al. Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden. The Lancet Gastroenterology & Hepatology 17 August 2020; doi: 10.1016/ S2468-1253(20)30267-3

Tags: Europe | Gastroenterology | North America | Pharmaceuticals

Printer friendly page Printer friendly page

Comment on this article:

<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)