SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Skin contact affects babies' pain response
Fri September 25th - Skin to skin contact between a parent and newborn baby reduces the infant’s response to pain, a new study has found. More
Human heart atlas could guide personalised treatments
Fri September 25th - A cellular and molecular map of the healthy human heart has been created to help clinicians understand what goes wrong in cardiovascular disease. More
RECENT COMMENTS
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...
BOOKS ON WOMEN'S HEALTH
guide to breast disorders guide to womb disorders guide to menopause Complete Women's Health: from The Royal College of Obstetricians and Gynaecologists For books and family gift ideas click here
OTHER NEWS OF INTEREST
WOMEN'S HEALTH NEWS FEED
RSS graphic XML Graphic
ENGLEMED HEALTH NEWS

Using frozen embryos does not increase pregnancy success

Thursday August 6th 2020

Using frozen embryos as part of assisted reproductive treatment does not increase the chances of pregnancy when compared with fresh embryo transfer, a new study published today (5 August 2020) says.

Researchers from Denmark, Sweden and Spain say their findings, which are published in The BMJ, suggest that fresh embryo transfer should be the gold standard, despite a freeze-all strategy becoming more common as it can minimise the risk of ovarian hyperstimulation syndrome.

This study examined if a freeze-all strategy resulted in a higher pregnancy rate than a fresh transfer strategy and involved 460 women, aged 18-39 years with regular menstrual cycles starting their first, second, or third treatment cycle of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) at fertility clinics at eight public hospitals in Denmark, Sweden, and Spain.

The women were randomised to one of two treatment groups, with the freeze-all group receiving gonadotropin releasing hormone to trigger egg maturity, followed by a single blastocyst transfer.

The fresh transfer group received human chorionic gonadotropin to trigger egg maturity, followed by a single fresh blastocyst transfer.

Women in the fresh transfer group with an excess number of mature follicles on the day of triggering had elective freezing of all embryos and transfer was delayed as a safety measure.

Lead study author Dr Sacha Stormlund, of Hvidovre University Hospital, Denmark, said the results show that the pregnancy rate, which was defined as a detectable foetal heart beat after eight weeks of gestation, did not differ significantly between the freeze-all and fresh transfer groups, with 62 out of 223 (27.8%) in the former group compared with 68 out of 230 (29.6%).

There was also no significant difference in the live birth rate, with 61 out of 223 (27.4%) for the freeze-all group and 66 out of 230 (28.7%) for the fresh transfer group.

The researchers also found no significant differences for pregnancy loss between the two groups, while none of the women had severe ovarian hyperstimulation syndrome.

There was a higher average birth weight after frozen blastocyst transfer and an increased risk of prematurity after fresh blastocyst transfer, while time to pregnancy was longer in the freeze-all group.

The researchers say a safe, fresh embryo transfer strategy can be applied to women with regular menstrual cycles with strict cancellation criteria for the fresh transfer if an excess number of mature follicles are present.

“The findings warrant caution in the indiscriminate application of a freeze-all strategy when no apparent risk of ovarian hyperstimulation syndrome is present,” they conclude.

Stormlund S, Sopa N, Zedeler A et al. Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles: multicentre randomised controlled trial. BMJ 6 August 2020. DOI: 10.1136/bmj.m2519

https://www.bmj.com/content/370/bmj.m2519

Tags: Childbirth and Pregnancy | Europe | Women's Health & Gynaecology

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES