SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Google

WWW Englemed
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Gene therapy programme launched for neurodegenerative diseases
Fri July 30th - An innovative gene therapy programme has been launched that could lead to novel treatments for neurodegenerative diseases. More
Unvaccinated pregnant women hospitalised with COVID-19
Fri July 30th - Pregnant women are being urged to have the COVID-19 vaccination after 200 were admitted to hospital last week with the virus – almost all of whom were unvaccinated. More
RECENT COMMENTS
On 09/10/2020 William Haworth wrote:
How long is recovery time after proceedure... on Ablation cuts atrial fibrillat...
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
OUR CLIENTS
THIS WEEK'S STORIES
ENGLEMED HEALTH NEWS

Protective benefit of exercise on liver cancer

Wednesday April 15th, 2020

Australian researchers have reported new discoveries about the protective effect of exercise against liver cancer.

It appears to be protective against the disease regardless of body weight, according to tests on animals.

A team of researchers led by Dr Geoffrey Farrell of the Australian National University in Canberra, Australia, looked at whether and how exercise can prevent liver cancer.

The researchers used lab mice that were genetically driven to eat so that they become obese and develop type 2 diabetes as young adults, then were injected with a low dose of a cancer-causing agent.

The animals were split into two groups, with one having no access to exercise and the other having regular access to a running wheel, leading them to run for up to 40 kilometres a day.

After six months all of the mice were obese, however most of the sedentary mice had liver cancer while none of the exercising mice had developed it.

Dr Farrell says: “As yet there are very few effective therapies for liver cancer so approaches to prevent liver cancer are greatly needed. Some population data suggest that persons who exercise regularly are less likely to develop liver cancer but, studies addressing whether this has a real biological basis, and, if so, identifying the molecular mechanism that produces such a protective effect, are few and the findings have been inconclusive.”

So the team set out to identify the molecular signalling pathways involved. They found that the stress-activated protein kinase JNK1 can be “switched off” by exercise, and that the tumour suppressor gene p53 regulates the cell cycle inhibitor, p27, stopping the persistent growth of potentially cancerous cells.

Results appeared in the Journal of Hepatology yesterday (14 April).

Arfianti, A. et al. Exercise retards hepatocarcinogenesis in obese mice independently of weight control. Journal of Hepatology 14 April 2020; doi: 10.1016/j.jhep.2020.02.006

https://doi.org/10.1016/j.jhep.2020.02.006

Tags: Australia | Cancer | Fitness | Internal Medicine

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES