SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Mental and physical health links a global issue
Wed July 17th - Action is needed on the physical health inequalities faced by people with mental illness, according to a major global study published today. More
Mixed findings for iron status
Wed July 17th - New research has found a mixture of positive and negative effects of having naturally higher iron levels. More
Regeneration device tested for myocardiopathy
Wed July 17th - A patient has successfully been implanted with a new microcurrent generator, developed to stimulate recovery from myocardiopathy, Austrian doctors have announced. More
RECENT COMMENTS
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...
OTHER NEWS FEEDS OF INTEREST
ENGLEMED HEALTH NEWS

Stem cell discovery could change vascular disease treatment

Friday May 10th, 2019

UK researchers have discovered a non-intrusive way to generate large quantities of stem cells using only a small amount of blood, it has been announced.

The team at Queen’s University Belfast and King’s College London (KCL) reveal today (9 May 2019) they also found the stem cells produced can generate and replace damaged cells within blood vessels.

They say this could prevent a range of vascular-related complications, including heart attacks, kidney disease, blindness and amputations in people with diabetes.

The preclinical study, published in Stem Cell Journals, showed that stem cells expressing the Endothelial Specific Molecule 1 (ESM1) gene have excellent regenerative potential and increase the blood-flow when they were tested in damaged blood vessels.

Principal investigator Dr Andriana Margariti, from the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, described the findings as potentially revolutionary for how some blood vessel diseases are treated.

“Being able to produce large quantities of stem cells from a few millilitres of blood in a short timeframe is truly ground-breaking. This could revolutionise how we treat a vast number of blood vessel diseases,” she said.

“Previously, this cell transformation process would have involved a skin biopsy, or large volumes of blood, which simply isn’t viable for many patients as it is a risky process which can take a long recovery time.”

The research team discovered that activating Endothelial Specific Molecule 1 (ESM1) in the stem cells could enhance the production and function of newly generating endothelial cells, which play a key role in several vascular diseases. Cell therapy can be used to repair damage through the transplantation of healthy endothelial cells.

Professor Alan Stitt, Dean of Innovation and Education at Queen’s University Belfast and co-author said: “Through the technology developed, we can readily produce stem cells to transplant to damaged blood vessels.

“We have discovered that activating the particular gene ESM1 will improve the production and function of endothelial cells, reversing the damaged cells. This is life-changing as the results have shown that repairing these cells can stop the progressive illnesses, which will prevent blindness and amputations.”

Although the study focused on stem cells for vascular diseases, the researchers believe the same process could be used to produce stem cells for other organs, paving the way for further innovative treatments.

Vilà-González M, Kelaini S, Magee C et al. Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling. Stem Cells Journals 9 May 2019

https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2936

Tags: Heart Health | UK News

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES