SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Hospitalised COVID-19 patients suffer symptoms for months
Tues October 20th - Many hospitalised COVID-19 patients were still experiencing symptoms of breathlessness, fatigue, anxiety and depression up to three months after contracting the virus, according to a new study. More
RECENT COMMENTS
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...
OUR CLIENTS
THIS WEEK'S STORIES
ENGLEMED HEALTH NEWS

Olaparib promising for advanced prostate cancer

Tuesday December 3rd, 2019

A gene-targeted medicine, for breast and ovarian cancer, shows promise for some men with advanced prostate cancer, the results of a new clinical trial have shown.

More than 80% of men with advanced prostate cancer whose tumours had mutations in the BRCA genes responded well to treatment with olaparib, the research out today says.

The phase II TOPARP-B trial found that patients whose prostate cancers had DNA repair defects lived for more than 13 months on average when treated with olaparib. This increased to nearly 18 months among those with BRCA mutations.

TOPARP-B, led by a team at The Institute of Cancer Research, London, UK, and The Royal Marsden NHS Foundation Trust, is the first study to treat men whose prostate cancers had mutations in their DNA repair systems with olaparib. The findings are published in The Lancet Oncology.

The trial involved 98 men, at 17 UK hospitals, with mutations in DNA repair genes, and who all had advanced cancer which had been heavily pre-treated.

The team found that 47% with DNA repair defects – mostly in the BRCA1 and BRCA2 genes, but also other mutations were also detected including those in the PALB2, ATM and CDK12 genes – responded to olaparib, stopping disease progression for an average of 5.5 months.

More than 80% of men with BRCA mutations responded best to olaparib, 40% of whom remained free of disease progression for more than a year.

More than half of patients carrying PALB2 mutations also responded to olaparib, as well as 37% with ATM mutations and 20% with other DNA repair gene alterations.

The median overall survival with olaparib was 17.7 months for patients with BRCA mutations, compared with 16.6 for men with ATM mutations, and 13.9 months for those with PALB2 mutations.

The researchers say the results suggest men with advanced prostate cancer should now routinely have their tumours tested for DNA repair defects such as BRCA mutations- so that where appropriate they can benefit from PARP inhibitors.

Study leader Professor Johann de Bono, Regius professor of cancer research at The Institute of Cancer Research, London, and consultant medical oncologist at The Royal Marsden NHS Foundation Trust, said: “Our trial has shown that men with prostate cancer who were selected for faults in DNA repair genes responded very well to the targeted drug olaparib, especially where they had BRCA mutations in their tumours.

“This study and another phase III trial place olaparib on the verge of becoming the first genetically targeted treatment in prostate cancer. I’m excited by these findings, and keen to see further research assessing how we can combine olaparib with other treatments to extend patients’ lives even more dramatically.”

Professor Paul Workman, chief executive at The Institute of Cancer Research, London, added: “Precision medicines targeted to specific genetic faults are transforming treatment for many different cancers, and with this new research it looks like we will soon be able to add prostate cancer to that list. It’s exciting to see a drug which the ICR helped pioneer having such widespread benefits for both women and men with cancer.”

Lancet Oncology 3 December 2019

Tags: Cancer | Men's Health | Pharmaceuticals | UK News

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES