Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
Salt regulation changes linked to disease rise
Fri July 19th - The end of government regulations on salt content in food is linked to thousands of extra cardiovascular disease and stomach cancer cases in England, it was claimed today. More
Diabetic women at increased risk of heart failure
Fri July 19th - Diabetes increases the risk of heart failure, particularly in women, a global study of 12 million people has found. More
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote: on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...

Plan to revive 50s meningitis treatment

Thursday April 11th, 2019

A strategy for treating bacterial meningitis abandoned in the 1950s could be brought back into use to help overcome drug resistance, Swedish researchers have reported.

The discovery emerged from Swedish research into how the immune system reacts when it is overwhelmed by infection from meningitis bacteria.

This led them to explain how the 1950s treatment, developed in the USA, works.

At the time scientists noticed lumps in the cerebrospinal fluid and discovered they could be dissolved by using DNase drugs.

Combined with new antibiotics, this reduced mortality rates from 30% to 20% - but was ultimately abandoned because the DNase drugs in use at the time were extracted from animals and triggered serious allergic side-effects.

Researchers at Lund University have now discovered the lumps are caused by a "last-ditch" response by neutrophils, using a kind of netting to capture bacteria.

The cells create Neutrophil Extracellular Traps – NETs – with the aim of transporting bacteria to organs such as the spleen. In meningitis, they found, using rat models, the NETs get trapped in the cerebrospinal spaces – but can be broken up with the DNase enzyme.

Unlike in the 1950s, the researchers were able to use a DNase drug derived from humans.

The findings were reported in Nature Communications.

Researcher Adam Linder said: "At that time, everyone was so happy about the antibiotics, they reduced mortality for the infections and it was thought that we had won the war against bacteria. I believe we need to go back and take up a part of the research that took place around the time of the breakthrough for antibiotics.

"We can perhaps learn from some of the discoveries that were then flushed down the drain."

Nature Communications 10 April 2019

Tags: Brain & Neurology | Europe | Genetics

Printer friendly page Printer friendly page

Comment on this article:

<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)