SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Malaria vaccination begins
Wed April 24th - The first ever national malaria vaccine campaign was launched yesterday in the African country of Malawi. More
Hope for repairing foetal membranes
Wed April 24th - New discoveries could enable successful treatment of ruptured foetal membranes, British researchers have reported. More
Gene link to cannabis addiction
Wed April 24th - Genetics plays a role in individual risk of becoming addicted to cannabis, British researchers reported today. More
RECENT COMMENTS
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...
BOOKS ON WOMEN'S HEALTH
guide to breast disorders guide to womb disorders guide to menopause Complete Women's Health: from The Royal College of Obstetricians and Gynaecologists For books and family gift ideas click here
OTHER NEWS OF INTEREST
WOMEN'S HEALTH NEWS FEED
RSS graphic XML Graphic
ENGLEMED HEALTH NEWS

SHBG hormone levels linked to reduced asthma risk

Tuesday April 2nd, 2019

Increased circulating levels of sex hormone regulator SHBG could be linked to a reduced risk of asthma, particularly in women, a new study has shown.

It is the first time that evidence has been found to demonstrate that sex hormone levels could have a role in explaining the observed gender difference in asthma prevalence.

Researcher at the University of Bristol, England, used measurements of SHBG and total testosterone, taken every two years from 513 boys from the age of nine to 17 who participated in the Children of the 90s Study (ALSPAC), which has been tracking the health of thousands of people born in the Avon region of England since 1991-2.

Information on asthma symptoms was supplied by the boys’ mothers when they were aged 10 and 13, and by the participants themselves at the ages of 16 and 22.

The researchers then pooled genetic data on asthma from more than 460,000 participants in the UK Biobank and the Trans National Asthma Genetics Consortium, applying Mendelian randomisation.

The observational data indicated that higher levels of circulating testosterone in teen boys were weakly associated with lower asthma risk, but no strong links were evident for SHBG levels.

The genetic data, however, indicated that higher levels of SHBG were associated with about 14% lower odds of asthma, although this effect was mostly seen in women.

The findings are published in the latest online edition of Thorax.

“Although previous hypotheses have suggested an immunological/inflammatory effect of SHBG on asthma, Mendelian randomisation does not distinguish between which mechanistic pathways link the exposure to the outcome. Therefore, any indication of SHBG’s causality does not imply a biological or immunological effect of sex hormones,” say the researchers.

In a linked podcast, lead author Dr Ryan Arathimos, said: “We found a protective effect of increased SHBG on asthma and observed that this was stronger in females. But we couldn’t distinguish whether the effect was sex specific – so if the effects of SHBG on asthma only exist in females – and our study design didn’t permit us to say if the protective effects of SHBG are in childhood, puberty, or adult life.

“We don’t know exactly which hormone or combination of hormones, be it testosterone or oestrogen, is having the effect on asthma, so further work is definitely required to disentangle the pathways involved.”

Arathimos R, Granell R, Haycock P et al. Genetic and observational evidence supports a causal role of sex hormones on the development of asthma. Thorax 2 April 2019; doi 10.1136/thoraxjnl-2018-212207.

Tags: Allergies & Asthma | Child Health | UK News | Women's Health & Gynaecology

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES