Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
Exercise benefits heart and blood sugar
Wed Jan 16th - Cardiology experts have published a position paper urging doctors to prescribe exercise for people with type 2 diabetes and cardiovascular disease. More
Breast cancer risk calculator unveiled
Wed Jan 16th - A new method of calculating breast cancer risk is to be available for wide use by primary care practitioners and genetic counsellors, it has been announced. More
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote: on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...

Breakthrough for lab-grown kidney research

Monday February 12th, 2018

Laboratory generated human kidney tissue has successfully been implanted and grown in living organisms for the first time, British researchers have announced.

The tissue, grown in mice, is able to produce urine, researchers said.

Professor Adrian Woolf, of Manchester University, UK, leader of the research with Professor Sue Kimber, said he was “tremendously excited” by the discovery.

The researchers generated kidney glomeruli from human embryonic stem cells grown in laboratory culture dishes containing culture medium.

These were combined with a gel-like substance, which acted as natural connective tissue, and injected as a tiny clump under the skin of mice.

After three months, nephrons had formed, containing most of the constituent parts present in human nephrons, including proximal tubules, distal tubules, Bowman’s capsule and Loop of Henle.

Capillaries had also developed inside the mice, but they lacked a large artery, they write in the latest edition of Stem Cell Reports.

To test the structures’ functionality, the team used the fluorescent protein Dextran to track and detect tubules, thereby demonstrating that filtrate was being produced and excreted as urine.

Professor Kimber said: “We have proved beyond any doubt these structures function as kidney cells by filtering blood and producing urine - though we can’t yet say what percentage of function exists.

“What is particularly exciting is that the structures are made of human cells, which developed an excellent capillary blood supply, becoming linked to the vasculature of the mouse.

“Though this structure was formed from several hundred glomeruli, and humans have about a million in their kidneys, this is clearly a major advance. It constitutes a proof of principle- but much work is yet to be done.”

Professor Woolf said while the success of the research was very exciting, the next step was to develop an exit route for the urine and a way to deliver the technology to diseased kidneys.

The Medical Research Council and Kidney Research UK funded the project, which is supported by the University of Manchester’s School of Biological Sciences, Manchester Regenerative Medicine Network (MaRM), and Kidneys for Life.

Bantounas I, Ranjzad P, Tengku F. Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors. Stem Cell Reports 8 February 2018; doi:10.1016/j.stemcr.2018.01.008 [abstract]

Tags: Internal Medicine | UK News

Printer friendly page Printer friendly page

Comment on this article:

<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)