SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
Handgrip test for lung cancer survival chances
Fri April 20th - Testing handgrip strength can help predict the survival chances of patients with non-small cell lung cancer, a conference will hear this weekend. More
NHS genomics project “at risk” - MPs
Fri April 20th - Ambitious plans to make the NHS a world leader in genomics are at risk, MPs warn today. More
RECENT COMMENTS
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
On 12/03/2017 Steph wrote:
The photo you have paired with this article is its... on 'Fat shaming' limits...
OUR CLIENTS
THIS WEEK'S STORIES
ENGLEMED HEALTH NEWS

Enzyme has double role in cancer

Wednesday December 13th, 2017

An anti-ageing enzyme may also help cancer cells survive chemotherapy, British researchers have found.

The NEIL3 enzyme is a type of DNA glycosylase protein, a family of enzymes involved in base excision repair - the mechanism by which damaged bases in DNA are removed and replaced.

It has previously been linked to protection from dementia and cancer because of its ability to repair oxidative damage.

However, experiments by Dr Rhoderick Elder of the University of Salford, UK, and colleagues indicate that NEIL3 can undermine chemotherapy by preventing cell death.

They explain in Scientific Reports yesterday (12 October) that some chemotherapy drugs create cross-links which prevent the DNA from replicating before cell division, leading to cancer cell death. But NEIL3 allows cancer cells to unhook these cross-links, they report.

The team collaborated with researchers at the Universite Paris-Sud, France, to view the effect of NEIL3 on cross-links using synthetic DNA.

Dr Elder says: "The protein appears to be allowing the cancer cells to overcome a problem that might otherwise be terminal for them; so rather than be locked in and die, they can escape, duplicate and the cancer continues to grow. A previous study on mice cells showed that cells are more sensitive to certain types of chemotherapy when NEIL3 is not present, and we were intrigued as to why. If we can inhibit NEIL3, it could potentially remove a barrier to the effectiveness of certain treatments."

They are now working on precise ways of knocking out NEIL3 with gene editing tools.

Martin, P. R. et al. The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. Scientific Reports 12 December 2017; doi: 10.1038/s41598-017-17693-4 [abstract]

Tags: Cancer | Pharmaceuticals | UK News

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES