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Hope for breast cancer prevention

Monday February 17th, 2014

Drugs could be available to help some women at high risk of breast cancer, British researchers have revealed.

A Manchester University study has centred on women with highly dense breast tissue.

These women are known to be at risk from cancer - and the new research has identified a cellular communication network that lies behind the problem.

The researchers say the JNK1 network has been well studied - and there are drugs that can block its action.

JNK1 is known to play a role in triggering inflammation.

The findings have been reported in the journal Cell Cycle.

The researchers say that diet and lifestyle might play a part in triggering the process.

Researcher Professor Michael Lisanti said: “What no one has fully appreciated before are the underpinning mechanisms at play. Using a bioinformatics approach, we have identified the relevant signalling pathways that make dense breast tissue more favourable for tumour formation.

“This signalling pathway could be used as a biomarker to identify women at higher risk of breast cancer more accurately and earlier than the current methods."

Professor Tony Howell, an expert on the subject at the university, said: “At least 50% of cancer risk is genetic, but activated cell stress signalling could potentially be reduced by dietary or lifestyle intervention.

"This research should help with a cancer prevention strategy, rather than waiting to treat the cancer once it arrives.”

Cell Cycle February 2014

Tags: Cancer | Pharmaceuticals | UK News | Women’s Health & Gynaecology

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