SIGN UP FOR UPDATES!
Sign up for Englemed updates from TwitterSign up for Englemed updates from Facebook
ENGLEMED
Contact Englemed
Our contact email address.
We can provide a specialist, tailored health and medical news service for your site.
Click here for more information
RSS graphic XML Graphic Add to Google
About Englemed news services - services and policies.
Englemed News Blog - Ten years and counting.
Diary of a reluctant allergy sufferer - How the British National Health Service deals with allergy.
BOOKS AND GIFTS THIS WAY!
BookshopFor books on women's health, healthy eating ideas, mental health issues, diabetes, etc click here
SEARCH THIS SITE
Google

WWW Englemed
Copyright Notice. All reports, text and layout copyright Englemed Ltd, 52 Perry Avenue, Birmingham UK B42 2NE. Co Registered in England No 7053778 Some photos copyright Englemed Ltd, others may be used with permission of copyright owners.
Disclaimer: Englemed is a news service and does not provide health advice. Advice should be taken from a medical professional or appropriate health professional about any course of treatment or therapy.
FreeDigitalPhotos
www.freedigitalphotos.net
FreeWebPhotos
www.freewebphoto.com
FROM OUR NEWS FEEDS
How heart failure risk rises after surgery
Wed June 29th - The development of atrial fibrillation following surgery is an important risk factor for heart failure, researchers report today. More
Brain surgery benefits intracranial pressure
Wed June 29th - Craniectomy for intracranial hypertension offers significant benefit, according to new guidance, triggered by British research. More
RECENT COMMENTS
On 09/10/2020 William Haworth wrote:
How long is recovery time after proceedure... on Ablation cuts atrial fibrillat...
On 08/02/2018 David Kelly wrote:
Would you like to write a piece about this to be i... on Researchers unveil new pain re...
On 23/10/2017 Cristina Pereira wrote:
https://epidemicj17.imascientist.org.uk/2017/06/21... on HIV breakthrough - MRC...
On 12/09/2017 Aparna srikantam wrote:
Brilliant finding! indeed a break through in under... on Leprosy research breakthrough...
On 01/07/2017 Annetta wrote:
I have been diagnosed with COPD for over 12 years.... on Seaweed plan for antimicrobial...
OTHER NEWS FEEDS OF INTEREST
ENGLEMED HEALTH NEWS

Anenome drug may curb obesity

Monday June 3rd, 2013

A new compound has been identified that may form the basis of a drug to tackle obesity.

Researchers led by Dr George Chandy and his colleagues at the University of California Irvine, USA, investigated compounds that may boost the metabolism.

They discovered a synthetic compound called ShK-186, originally derived from a sea anemone, could enhance metabolic activity and may benefit people with insulin resistance.

ShK-186 works by blocking an inflammation protein that works via the Kv1.3 potassium channel. Potassium channels regulate a variety of cellular processes, explain the researchers. Previous studies on mice that lack a potassium channel gene suggested that the gene helped regulate the basal metabolic rate, and therefore body weight.

The compound ShK-186 was given to obese mice put on a high-fat, high-sugar diet. It reduced their weight gain, white fat deposits, fatty liver, blood cholesterol and blood sugar. It did so by activating calorie-burning brown fat, suppressing inflammation of white fat and increasing healthy liver function.

These tests also showed that Kv1.3 activity is raised in the first place by the mice's obesity-causing diet. Full details appear in yesterday's (28 May) Proceedings of the National Academy of Sciences.

The drug has been licensed by Kineta, a Seattle-based drug company which is now developing ShK-186 to treat metabolic syndrome and obesity, as well as autoimmune diseases such as multiple sclerosis, psoriatic arthritis and lupus. It showed positive results in a Phase 1 safety clinical trial in March 2013.

Dr Chandy says: "These data are quite exciting and strongly support the notion that inhibition of the Kv1.3 channel provides a highly effective method for managing obesity and its associated metabolic abnormalities."

Chandy, G. et al. Proceedings of the National Academy of Sciences 28 May 2013, Volume 110 number 21.

Tags: Diet & Food | North America | Pharmaceuticals

Printer friendly page Printer friendly page

Comment on this article:

Name:
Email:
Comment:
<a>,<b> & <p> tags allowed
Please enter the letters displayed:
(not case sensitive)
CATEGORIES