Skin gene linked to allergy risk
Friday July 10th, 2009
New research has linked allergies such as eczema, rhinitis, and asthma to a specific gene.
About one in ten people have defects to the "filaggrin" gene. These defects make it more likely that the individual will suffer from an allergy, say researchers from Edinburgh University, UK.
They explain on the website of the British Medical Journal that, until recently, no clear genetic links have been found with allergy risk. The team investigated the filaggrin gene because it helps maintain an effective skin barrier against the environment.
They analysed the results of 24 studies and found that filaggrin gene mutations significantly increase the risk of "allergic sensitisation". The link with eczema was particularly strong.
"These findings provide strong supporting evidence that, at least in a subset of those with allergic problems, the filaggrin gene defect may be the fundamental predisposing factor not only for the development of eczema but also for initial sensitisation and progression of allergic disease," say the authors.
"Our findings suggest that filaggrin is a robust biomarker for allergic conditions," they add.
They conclude: "Defective function of the skin barrier may be fundamental in people with allergic disorders."
It is possible that in future, the filaggrin gene will be used to identify people at high risk. The experts also believe that improving the skin barrier in people at high risk may prevent allergic sensitisation and the development of allergies.
Tags: Allergies & Asthma | Dermatology | Genetics | Respiratory | UK News
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